I've heard many times from Pritzker students that Pritzker is where "fun goes to die." I know that isn't really informative but just saying...
Wow, that was not my impression! I know that the U of Chicago undergrad has a rep for being pretty intense, but I did not get the sense that students at the med school had less fun than their counterparts at other schools. (edited to add: copingmethods got here before me
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The schools have a lot in common - both are tweaking their curricula next year, both are p/f, and both are in more affordable (and less exciting) neighborhoods of big cities. Both are big into student activities (columbia has the p&s club and chicago has as many clubs as they have students). Both are in cities with scads of other medical schools.
I am making a similar choice and here are some of the differences I observed:
Class size: Columbia is nearly double the size (which I see as a pro and a con)
Student body: Columbia students seemed a bit "cooler" and maybe a bit preppier to me, Chicago students seemed quirkier. (this is just my impression).
Neighborhood: I think I would like living in both of these neighborhoods, but Hyde park wins for cost of living
Student housing: most of the class lives in dorms for Columbia 1st year, which qualifies you to live in their sweet towers after that (but only if you suck it up in the dorm for a year IIRC). pretty much no one lives in dorms at Pritzker since Hyde park is not expensive.
Undergrad institution: I haven't looked this up, but it seemed like a LOT of students at Columbia went to Ivies undergrad, versus a bigger range of undergrad schools at Pritzker
Relationship to its own undergrad inst: Columbia is 70 blocks ( a quick train ride) away from the main campus, Pritzker is right on the main campus (pros and cons to this too, i think).
Non-trads: Don't know if this matters to you, but I met more non-trads at Pritzker vs. Columbia. Neither of their websites are good enough for me to quickly verify this
Diversity: Again, don't know if this matters to you, and I find their numbers hard to compare since Columbia lumps together all "minority" (which I would guess includes AA, latino and s. asian) while Pritzker divides it up into AA, latin american and asian (combining e. asian and s.asian) Bottom line - similar rates (i think?) but columbia's minority community is bigger since it's a bigger school.
Research and Community Service: Both do plenty of both, but Columbia students seemed a bit more research-oriented and Pritzker students seemed a bit more CS oriented (but a very marginal difference).
Again this is just my impression of all of this - feel free to PM me if you want to talk more about these two schools