Yes it does.
I'm currently getting anxious that I won't make any good friends in vet school. I'm...shall we say unusual? I get along pretty well with everyone, but there are very few people I really click with. For example, at my high school of 2500, there were maybe four people who I was sort-of friends with, and at my undergrad school of 3,000, there were only about 10 people per year I was really friends with - and I spent time with people in lots of majors, clubs, and different dorms, as well as lots of friends of friends, trying to find more people I got on well with. In a class of ~140, the odds are pretty good that there won't be anyone I'll click with, or that the one or two people I would are too busy/have other friends and thus will not have time for me. I'm not antisocial, or particularly shy. I have lots and lots of "friendly aquaintances" in pretty much every setting I've ever been in. I just don't find many people who become good friends.
Plus, I do/enjoy/find important several things that people on this forum seem to find annoying/angering/off-putting. I can only assume that these things will annoy/anger/put off a lot of my classmates as well.
I'm getting worried that I will have to get through vet school without a social support network.