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I've never thought of whether or not it's "required" but most schools expect an updated transcript, some schools even wait for an updated transcript to decide whether or not to call you in for an interview/give you an acceptance. So in the end, yes you should still send it in.
Yeah, many of the PharmCAS schools I applied to wouldn't consider my application to be complete until they offered interviews. To cover all bases, I would use academic update too,