Confusion in diagnosis of Smoldering multiple myeloma , MM vs plasmacytoma

[DrAmygdala]

If there is single bony lesion biopsy-proven plasma cells, BM biopsy showing 1% plasma cell, serum-free light chain ration 0.12, and monoclonal protein in the range of 1.3k. Will it be considered Smoldering MM, MM or plasmacytoma?

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[DoctorDontStop]

If there is single bony lesion biopsy-proven plasma cells, BM biopsy showing 1% plasma cell, serum-free light chain ration 0.12, and monoclonal protein in the range of 1.3k. Will it be considered Smoldering MM, MM or plasmacytoma?

If there is single bony lesion biopsy-proven plasma cells, BM biopsy showing 1% plasma cell, serum-free light chain ration 0.12, and monoclonal protein in the range of 1.3k. Will it be considered Smoldering MM, MM or plasmacytoma?

Plasmacytoma, refer to Rad Onc

 

[Smoothbrain]

Plasmacytoma, refer to Rad Onc

A bone marrow biopsy of 1% plasma cells is normal.

A plasmacytoma is a localized tumor of plasma cells with absent or low serum urine M protein.

For diagnosis plasma cell myeloma you need >30g/L serum M component or 10% clonal plasma cells in bone marrow or evidence of myeloma-related symptoms

For diagnosis of smoldering myeloma (asymptomatic myeloma) you need >30 g/L and/or 10% or more clonal plasma cells in bone marrow AND no related organ tissue impairment (CRAB symptoms)

 

[bobow98]

After the plasmacytoma is treated definitively by radonc you will notice the paraproteins subsiding.
I'm assuming you've done a PET CT to rule out other lesions and involved areas?