As someone who foolishly applied to MD/PhD programs and managed to get into one straight out of undergrad, I would say do not go where you don't want to. I made the wrong decision because I was interested in research. I wasn't the most competitive applicant, so I was pumped when I got in. I didn't pause to think how MUCH research I wanted to do.. and now I'm entering my 7th year of the program and I hate the city, I hate the graduate program. Everyone I entered medical school with has graduated and moved on, and the ones that entered the MD/PhD with me are leaving soon. I moved across the country to come here, and basically graduate school isolated me from everyone around me. I now have no support system here, and I'm still stuck here for at least two more years. It may be better for you since your wife is going with you, but think very carefully about how long you're willing to be in a place before you go. As some of the people have said, there will be other acceptances if you were meant to be a doctor.