Giving exogenous dopamine to treat prolactinoma and attention deficit disorder?

[as90]

Hi,
I was wondering, I know that carbegoline is used for prolactinomas and you would typically use a stimulant for ADHD, but is there a particular reason why dopamine itself cannot just be given?

Is it something to do with MAO and breakdown? I was wondering because we had a question on it and the prof did not elaborate on it. Was just curious.

Thanks so much

---

Members don't see this ad.

 

[loltopsy]

MAOs, MAOs everywhere.

Same reason why people taking DMT take an MAOI with it. So the effects last longer than 5 minutes. Like Parkinsons - they give L-Dopa to avoid MAOs and cross the BBB, and Carbidopa to comp inhib AAAD and allow less L-Dopa breakdown. Pituitary lacks BBB but yeah.