Oh surely!
I would interrogate that term "substantial," wondering if it means anything void of God, but I'll digress until the cows come home if you let me. Better if I attempt an answer directly.
That viewpoint, or at least the hazy notion of it I had floating around my head, resonated with me on levels ranging from the superficial to (what I consider) the profound.
Superficially, I was glad to no longer be at self-declared war with 90% of the human race. It was lonely being an atheist and obsessing about the destruction of all these rubes' mythical tosh. I found I would immediately judge a person as unstable or inferior in mind if they revealed that they...believed. I lost a girl I wanted to marry over my obstinacy and it took me awhile to forgive her for choosing her faith. Now, I can withstand someone's bumbling explanation of why God supposedly loves me or a circular prayer of gratitude without descending into a sputtering rage. I now believe they might have a point.
I also was able to forgive my own irrationality and shortcomings. It felt okay to be a human being again, because there's a lot of me I could never explain--to myself, never mind anyone else. It eased the pressure on my mind, because the truth no longer depended on my comprehension of it, nor my browbeating religious people about their inability to grasp it. There was...like...this inversion of thought that absolutely stunned me. I was funneling all action and beliefs through my valve of logic and empiricism, raging against all that which I thought "there was no evidence for," and I suddenly felt insane. Or at least that I was going to become so. I wondered how far I would take this--had I logically vetted my logic? Or empirically determined the value of empiricism? I got on that solipsistic train and it broke me the funk down. Seriously made me weep. I had to let go. If reason and truth and meaning and all these things I loved were to truly have meaning, I had to surrender to the possibility. The fact that I couldn't explain reason indicated to me it's okay not to always seek out explanations for why I think or act a certain way. I believe there is always an explanation, but I also believe it might be meant to lie outside my grasp. This softened me to people, replete with their emotional baggage and crazy behavior and beliefs that get them through it. I recognized myself in them!
And that last point has been instrumental for me in how I interact with others day-to-day (I'm not naturally empathetic). It's morphed into a desire to practice medicine, which led me to these boards, and now to this bloated forum post
I'm still agnostic about the whole God thing, but in that agnosticism is a hope (I think) that really shook me from a self-indulgent nihilism. Spector mentioned earlier how he doesn't believe nihilism is the exclusive domain of atheism, and I suppose I can kinda see his gist, but I would have to shelve a lot experientially if I were to come to the same conclusion. Which, just because I feel it, doesn't mean it's so. All the same, I do tend to lend a little more agency to others' life experience--religious anecdotes and such--because I think it's possible God speaks to each one of us in ways only that one person can understand. I imagine it's like a hidden conversation. Maybe there will be a conversation or a stray book passage or seemingly random event that rocks you to your core, and it's just perfectly tuned to your questions--eminently valid questions--and personality and experience. I dunno. I recognize a lot of myself in atheists, and I have an enduringly soft spot for them, even though I now typically avowedly disagree with what they're saying.