C
ClinPsycMasters
from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635536/
"Most recently, Kapur (2003) proposed that the positive symptoms of schizophrenia may arise out of the aberrant assignment of salience to external objects and internal representations, and that antipsychotic medications reduce positive symptoms, by attenuating aberrant motivational salience, via blockade of the dopamine D2 receptor."
"A corollary of this is that antipsychotic medications will also necessarily attenuate adaptive motivational salience, that is the correct assignment of salience. This may result not only in positive symptom remission, but also negative side-effects related to loss of motivation, such as apathy and anhedonia."
The study referred to is the seminal work by Kapur:
Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry. 2003;160:1323.
"Most recently, Kapur (2003) proposed that the positive symptoms of schizophrenia may arise out of the aberrant assignment of salience to external objects and internal representations, and that antipsychotic medications reduce positive symptoms, by attenuating aberrant motivational salience, via blockade of the dopamine D2 receptor."
"A corollary of this is that antipsychotic medications will also necessarily attenuate adaptive motivational salience, that is the correct assignment of salience. This may result not only in positive symptom remission, but also negative side-effects related to loss of motivation, such as apathy and anhedonia."
The study referred to is the seminal work by Kapur:
Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry. 2003;160:1323.