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My state is planning on having a vaccine distributed and available to us mid-December. Has sparked a lot of discussion...
Can't the measles vaccine or something cause some major brain problem in kids? I feel like that's a step1 question thing.For people who are wary, what are the potential downsides (other than Bill Gates/mind control)? In the history of vaccines, my understanding is that the worst outcomes have involved lots of people getting the disease being immunized against (polio). Getting COVID would be unfortunate, but certainly not as bad as polio. Are there other things I'm missing?
No, the Step 1 question is that the actual measles virus, that you get if you’re NOT vaccinated, can cause subacute sclerosing panencephalitis.Can't the measles vaccine or something cause some major brain problem in kids? I feel like that's a step1 question thing.
Lucky you. I filled stuff out like 5 times to join a trial but never got recruited.I’m in a covid vaccine trial so yes. I’ll get whatever is approved and recommended.
zombie apocalypseFor people who are wary, what are the potential downsides (other than Bill Gates/mind control)? In the history of vaccines, my understanding is that the worst outcomes have involved lots of people getting the disease being immunized against (polio). Getting COVID would be unfortunate, but certainly not as bad as polio. Are there other things I'm missing?
Several different mRNA vaccines have now been tested from phase I to IIb clinical studies and have been shown to be safe and reasonably well tolerated (Tables 2, 3). However, recent human trials have demonstrated moderate and in rare cases severe injection site or systemic reactions for different mRNA platforms22,91. Potential safety concerns that are likely to be evaluated in future preclinical and clinical studies include local and systemic inflammation, the biodistribution and persistence of expressed immunogen, stimulation of auto-reactive antibodies and potential toxic effects of any non-native nucleotides and delivery system components. A possible concern could be that some mRNA-based vaccine platforms54,166induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity167,168. Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken. Another potential safety issue could derive from the presence of extracellular RNA during mRNA vaccination. Extracellular naked RNA has been shown to increase the permeability of tightly packed endothelial cells and may thus contribute to oedema169. Another study showed that extracellular RNA promoted blood coagulation and pathological thrombus formation170. Safety will therefore need continued evaluation as different mRNA modalities and delivery systems are utilized for the first time in humans and are tested in larger patient populations.For people who are wary, what are the potential downsides (other than Bill Gates/mind control)? In the history of vaccines, my understanding is that the worst outcomes have involved lots of people getting the disease being immunized against (polio). Getting COVID would be unfortunate, but certainly not as bad as polio. Are there other things I'm missing?
Lucky you. I filled stuff out like 5 times to join a trial but never got recruited.
Oh yeah, damn, hang on, I gotta go let my facebook anti-vacc group know.No, the Step 1 question is that the actual measles virus, that you get if you’re NOT vaccinated, can cause subacute sclerosing panencephalitis.
Weird, I know of a couple military peeps where I am that underwent the trial.I wanted to, but we were told we (military) weren’t allowed. I will be getting the vaccine as soon as I’m able.
Weird, I know of a couple military peeps where I am that underwent the trial.
We can't?HCWs cant even get tested for covid and the tests are being saved for NBA all stars and celebrities, but somehow the life saving vaccine is gonna come to us first... seems fishy to me
Put it into my veins. Preferably the mRNA, but if the first one I can get is the adenovirus I’ll take that (then the sweet mRNA goodness)
I’m sure there is some unseen 1/100000 late autoimmune risk. I also think it Is quite likely there are rare long term complications of COVID which are a higher risk. And this way I won’t pass it to my grandmother.
The selfish worldview of those in our nation is a legitimate concern.
It's not a "rushed" process. It is a noncuttiong corner process that was done all simultaneously but safely at once. There was a lot of financial risk involved if any phases failed. Fortunately, everything has gone well, but nothing was accelerated in terms of leniency.From people I know:
1. Don’t trust rushed process
2. Don’t trust govt in general
3. High chance of flu-like sx, etc
4. The long term unknown
I don’t agree with them, it’s prob 50/50ish where I work.
It's not a "rushed" process. It is a noncuttiong corner process that was done all simultaneously but safely at once. There was a lot of financial risk involved if any phases failed. Fortunately, everything has gone well, but nothing was accelerated in terms of leniency.
If Trump gets it, every republican disbeliever will.Give it to me. I’m so over this “new normal” BS and really tired of wearing an N95 or half/full face respirator with each aerosolizing procedure.
The way things are shaping up the mRNA vaccines (Pfizer, Moderna) are going to the only ones available for a while. AstraZeneca’s results don’t meet their own internal benchmarks to ask for FDA approval anytime soon, apparently.
I do worry about distribution, a LOT. It looks like initially it’ll be handled by federal and state authorities (on the ground, mostly state probably). I wouldn’t be surprised if my region is skipped entirely (long story, but my metro area is always overlooked historically) and our governor, despite having an advanced degree, is a total mor0n (apparently the word is censored... really?).
Furthermore there’s a lot of folks out there who greatly distrust the government and won’t take it. Monumental efforts will be needed to convince Joe and Jane Public to get vaccinated. Maybe if you can get obnoxious reality stars and others to jump on board?
If Trump gets it, every republican disbeliever will.
Eventually, but not immediately. Will wait on side effect profile seen in early-adopters. Frankly, not that scared of getting the actual disease - all the colleagues I know who've gotten it have had mild symptoms lasting a couple of weeks and then were back to work. I'll continue to use personal protection to minimize my chances of getting it though; and who knows, I might've already had it and not have known it.
And my cousin who was relatively young and healthy is dead now. My classmate who got it in March still can’t do cardio without becoming extremely winded and lightheaded. Just not worth the risk IMO. Gimme that shot.
Eventually, but not immediately. Will wait on side effect profile seen in early-adopters. Frankly, not that scared of getting the actual disease - all the colleagues I know who've gotten it have had mild symptoms lasting a couple of weeks and then were back to work. I'll continue to use personal protection to minimize my chances of getting it though; and who knows, I might've already had it and not have known it.
Sincerely sorry for the loss of your cousin, but anecdotes mean nothing to me.
Eventually, but not immediately. Will wait on side effect profile seen in early-adopters. Frankly, not that scared of getting the actual disease - all the colleagues I know who've gotten it have had mild symptoms lasting a couple of weeks and then were back to work. I'll continue to use personal protection to minimize my chances of getting it though; and who knows, I might've already had it and not have known it.
Okay so then why are you using anecdotes to decide that the virus isn’t scary?Sincerely sorry for the loss of your cousin, but anecdotes mean nothing to me.
What's the rational for doing this?I’m so over this “new normal” BS and really tired of wearing an N95 or half/full face respirator with each aerosolizing procedure.
TRICARE recipients are a large arm of the Oxford vaccine trial. I could have enrolled - decided against it. I don't want to mess with my chance of getting an actual vaccine (since I wouldn't know if I got placebo or not).Weird, I know of a couple military peeps where I am that underwent the trial.
How’s your community positivity rates? Is your hospital overflowing yet?What's the rational for doing this?
I've been using a normal surgical mask since the beginning and haven't been infected as it should be if you just wear a mask.
TRICARE recipients are a large arm of the Oxford vaccine trial. I could have enrolled - decided against it. I don't want to mess with my chance of getting an actual vaccine (since I wouldn't know if I got placebo or not).
I suspect when a vaccine is available, I will be FORCED to get it.
So you might get it. And might give it to your patients. Some of whom might die. And you’re ok with that because seeing 50,000 people get it and do fine in the trials isn’t enough for you. Awesome.
That is a fair point, the short answer is maybe. We just don’t have enough information to say one way or the other. The vaccines dramatically reduced symptomatic and severe COVID cases, but (at least in the mRNA trials) they didn’t screen for asymptomstic infection. Is it possible that those cases were still occurring and equally infectious? Sure. But smart money says that there were fewer cases and those that occurred were less infectious with lower viral loads. Just like how you’re not considered a potential spreader of measles if you’ve had the vaccine.If someone gets vaccinated, or if someone has been infected in the past and now has antibodies to the virus - cant they still spread the virus?
Meaning they contract particles from someone else, their system is invaded but they dont get sick because they have the antibodies, but meanwhile they are breathing all over stuff and living life unaware their body is fighting off the covid particles.. what happens to those particles they are spreading around?
My impression was the vaccine prevents the individual from getting sick, but does not in and of itself prevent spread to someone who is unvaccinated.. im sure it cuts down on the time the person is contagious, but stop spread completely?
So your vaccine would not help grandma, grandma would also have to be vaccinated. RIght?
That is a fair point, the short answer is maybe. We just don’t have enough information to say one way or the other. The vaccines dramatically reduced symptomatic and severe COVID cases, but (at least in the mRNA trials) they didn’t screen for asymptomstic infection. Is it possible that those cases were still occurring and equally infectious? Sure. But smart money says that there were fewer cases and those that occurred were less infectious with lower viral loads. Just like how you’re not considered a potential spreader of measles if you’ve had the vaccine.
I suspect it's likely to be similar to the flu vaccine. It definitely decreases how infectious you are but doesn't eliminate the chance you could get someone else sick.Possibly, but again I can’t think of any other instance where a vaccine prevents symptomatic infection but doesn’t affect transmissibility/R0. Can anyone enlighten me?