Why are eosinophils & mast cells part of innate immunity?

[Ven0m]

If they carry IgE on their surfaces, why are they part of innate rather than adaptive?

Just found out they express TLRs, would this mean they are part of both innate (b/c TLRs) and adaptive (b/c IgE)?

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[wanderingorion]

The IgE was formed by the adaptive portion (B cells), but mast cells/eosinophils do not have the capacity to make targeted molecules like TCR/BCRs. A more accurate way to think about it is that they have Fcr's that bind the ends of the antibodies, so they can carry out the adaptive response to an antigen, but cannot produce them.

 

[Gurby]

The IgE was formed by the adaptive portion (B cells), but mast cells/eosinophils do not have the capacity to make targeted molecules like TCR/BCRs. A more accurate way to think about it is that they have Fcr's that bind the ends of the antibodies, so they can carry out the adaptive response to an antigen, but cannot produce them.

Look at this guy trolling the Step 1 forums 2 days after finishing M1... what a gunner

 

[wanderingorion]

Look at this guy trolling the Step 1 forums 2 days after finishing M1... what a gunner

just trying to spread what little knowledge I have around

 

[Ven0m]

The IgE was formed by the adaptive portion (B cells), but mast cells/eosinophils do not have the capacity to make targeted molecules like TCR/BCRs. A more accurate way to think about it is that they have Fcr's that bind the ends of the antibodies, so they can carry out the adaptive response to an antigen, but cannot produce them.

Thanks man!