I looked at the Head and Neck oropharyngeal outcomes via our cancer registry between the older and newer generation at 3 year survival and LRC. This is where I think contouring would make the biggest difference. Guess what...No difference. Therefore I have no line anymore.
But have fun talking to your online group to get your echo chamber needs fulfilled so you can sleep better knowing that you are superior to the person next to you!
Odd. One would have expected that stage migration (PET-CT) alone would have enhanced your results.
I could've told you "bad" versus "good" contouring doesn't make a lot of difference... even in head & neck. This was like plenary paper #002 at ASTRO 2008:
Variability in interobserver target volume delineation has raised concern over potential marginal misses in head and neck IMRT. It has been assumed that areas not designated as PTV may not receive tumoricidal doses. We investigated the dosimetric impact of inter-observer contouring variation by examining the dose to tissue outside of the PTV.
Materials/Methods
Plans from 10 sequential patients with locally advanced head and neck carcinoma (6 oropharynx, 4 larynx/hypopharynx) treated with definitive IMRT were evaluated. In accordance with current RTOG protocols, a high risk PTV70 (including all GTVs + 1 cm margin) received 70 Gy in 35 fractions, while elective regions in a low risk PTV received 56 Gy. To determine the dose to tissue outside of the PTV70, we performed 0.5 cm and 1 cm expansions of the PTV70 followed by subtractions of the original PTV70 to generate axial 0.5 cm and 1 cm “rings of tissue” concentric around the PTV70. Regions not at risk of harboring microscopic tumor (air cavities and the center of bone that did not abut GTV) were excluded from the tissue rings. DVHs were created for these rims, which were felt to be a surrogate for the tissue volume that is subject to reasonable interobserver variability.
Results
For the 0.5 cm rim of tissue surrounding the PTV70, the median dose to 95% of the volume (D95) was 61 Gy (range 50-60Gy), while the median D50 was 68.3 Gy (range 67-70 Gy). For the 1 cm rim surrounding the PTV70 the median D95 and D50 were 54.7 Gy (50-60 Gy), and 68.3 Gy (67-70 Gy) respectively.
Conclusions
While head and neck tumor GTV delineation is subject to significant interobserver variability in the axial dimension, there is still substantial dose to areas outside the PTV in the axial plane with IMRT planning such that an increase in marginal miss seems unlikely when transitioning from conventional to IMRT based planning. This agrees with published reports citing a predominance of central failures. IMRT establishes steep dose gradients near critical structures, but at the expense of dose “bulging out” into the remaining tissue. In contrast, with conventional fields, tissue 1 cm anterior or posterior to the PTV can receive less than 30% of the prescription dose and may actually present a greater potential for a marginal miss.