Methadone Deaths CDC

[Ducttape]

Factors independently associated with complicated inductions included recent use of prescribed methadone, recent benzodiazepine use, no prior experience with buprenorphine, and a low initial dose of buprenorphine/naloxone.

im sorry to harp on this, but these suggest caution in transitioning from methadone to suboxone, but do not rotation to morphine, going through withdrawal from methadone then potentially morphine, in order to be on long term suboxone.


of note, Amidon, the initial German name for methadone, was available for clinical trials in either fall 1942 or 1945. it was not extensively used by the Germans during WWII - morphine was still by far the most common and drug of choice. the initial scientists were looking for an antispasmodic, initially.

Eli Lilly named the drug Dolophine and released it in the US in 1947.

good read, most thorough out there:
http://ahahq.org/Bulletin/October_2007.pdf

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[101N]

More than one way to skin a cat. But, I've not lost sight of the big picture: the cat needs skinning.