Having lived in NYC for two years, I would say NO to an "upper middle class life style" which to me means a room for each child, feeling overall very comfortable in your living space, excellent schools,and able to support non-working spouse who would have option of staying home with child/children. On an primary doc salary, that means approximately 180 - 200k (competitive market pay cut), in a real estate market that is unbearably expensive (I know someone paying 7K/mos for a nicer/amenity filled,two bedroom apt in Midtown).
In NYC, on 200K/year you are most likely living in Queens/less desirable areas of Brooklyn/NJ, or a box (1-2 bedroom), less amenities, etc. Most people in NYC spend >50% of their after tax income on rent/(or mortgage for rarer home owner).
It's certainly not for me, although its nice to visit for good restaurants/museums/plays.
If you are single, or spouse is also working, then you could pull off something solid.