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In many situations you are having to choose between Etomidate and Propofol for your induction agent. In elderly patients for example who need intubation secondary to COPD or Cardiac related conditions the choice between Etomidate and Propofol isn't a good one. Our literature shows even transient hypotension is associated with worse outcome. Etomidate has been linked to worse outcome as well (controversial, debatable). The answer is a low dose combo of Propofol and Ketamine.
Ketofol as a Sole Induction Agent is Associated with Increased Hemodynamic Indices in Low-Risk Patients
Nathan J. Smischney, M.D., Michael L. Beach, M.D.,Ph.D., Thomas M. Dodds, M.D., Matthew D. Koff, M.D., M.S.
Mayo Clinic, Rochester, Minnesota, United States
Background:
Propofol is a non-opioid, non-barbiturate, sedative-hypnotic agent with rapid onset and short duration of action.1 However, there are several undesirable side effects such as cardiovascular and respiratory depression. Ketamine is a phencyclidine derivative commonly classified as a dissociative sedative with fairly rapid onset and short duration of action.2 It causes little or no respiratory and cardiovascular depression. However, ketamine can have some undesirable effects on hemodynamics (opposite of propofol). Effectiveness of the two agents in combination has been recently demonstrated and this new combination could allow a novel induction agent with favorable effects on hemodynamics. This study aimed to ascertain if a combination dose of ketamine and propofol (ketofol) would produce more favorable hemodynamics than the standard induction agent, propofol in healthy patients.
Methods:
In this randomized, double-blinded controlled trial, 85 pts of ASA Class 1-2 scheduled for surgical procedures that involved general anesthesia were assigned to one of two arms, one involving induction with propofol and the other involving induction with ketofol (ketamine/propofol combination). Patients were placed on standard ASA monitors including a BIS monitor and a noninvasive cardiac output monitor (NICOM) prior to induction of general anesthesia.
One minute before induction, baseline hemodynamics were recorded with standard ASA monitors as well as with the NICOM. Providers were given one 20ml syringe and one 10ml syringe for rescue if needed. As part of the induction, fentanyl (1-2mcg/kg) and any relaxant but succinylcholine and pancuronium were given. The 20ml syringe in both groups looked identical, appeared to be propofol but depending on the group they were randomized to, it represented either 2mg/kg of propofol (propofol group) or 0.75mg/kg of ketamine and 1.5mg/kg of propofol (ketofol group). The 10ml rescue syringe, if used, represented 1mg/kg of propofol (propofol group) or 0.25mg/kg of ketamine and 0.5mg/kg of propofol (ketofol group). Hemodynamics were recorded every minute for a total of 30 minutes post-induction. During this time, anesthesia was maintained with any volatile agent excluding nitrous oxide.
Primary analysis evaluated reductions in systolic blood pressure (SBP) of more than 20% from baseline. Secondary analysis evaluated amount of vasoactive agents used between the two groups as well as differences in pain and nausea/vomiting scores. Data was analyzed using an un-paired t-test, chi square or fisher's exact test as appropriate. A p-value of <0.05 was considered significant.
Results:
Comparison of the ketofol and propofol groups demonstrated a significant decrease of more than 20% in SBP from baseline in the propofol group at both 5 minutes (48.8%; 95% confidence interval [CI], 2.07 to 26.15, p=<0.001) and 10 minutes (67.4%; 95% CI, 1.21 to 8.75, p=<0.01). This was also significant for diastolic blood pressure and mean arterial pressure. At 30 minutes, there was no significant difference among the groups (p=0.39).
No significant differences were noted between groups with regard to preoperative vital signs, ASA status, or preoperative home medications. There was a trend towards higher vasoactive agent use in the propofol group as compared to the ketofol group during the 30 minute study period (p-value 0.07). No significant difference in case duration, intraoperative fluid administration, urine output, or estimated blood loss.
Conclusions:
A significant difference in systolic blood pressure, diastolic blood pressure and mean arterial pressure was noted between ketofol and propofol with ketofol demonstrating improved hemodynamics during induction of general anesthesia. Further study is needed to determine if this combination could be of benefit in high risk patients.
Ketofol as a Sole Induction Agent is Associated with Increased Hemodynamic Indices in Low-Risk Patients
Nathan J. Smischney, M.D., Michael L. Beach, M.D.,Ph.D., Thomas M. Dodds, M.D., Matthew D. Koff, M.D., M.S.
Mayo Clinic, Rochester, Minnesota, United States
Background:
Propofol is a non-opioid, non-barbiturate, sedative-hypnotic agent with rapid onset and short duration of action.1 However, there are several undesirable side effects such as cardiovascular and respiratory depression. Ketamine is a phencyclidine derivative commonly classified as a dissociative sedative with fairly rapid onset and short duration of action.2 It causes little or no respiratory and cardiovascular depression. However, ketamine can have some undesirable effects on hemodynamics (opposite of propofol). Effectiveness of the two agents in combination has been recently demonstrated and this new combination could allow a novel induction agent with favorable effects on hemodynamics. This study aimed to ascertain if a combination dose of ketamine and propofol (ketofol) would produce more favorable hemodynamics than the standard induction agent, propofol in healthy patients.
Methods:
In this randomized, double-blinded controlled trial, 85 pts of ASA Class 1-2 scheduled for surgical procedures that involved general anesthesia were assigned to one of two arms, one involving induction with propofol and the other involving induction with ketofol (ketamine/propofol combination). Patients were placed on standard ASA monitors including a BIS monitor and a noninvasive cardiac output monitor (NICOM) prior to induction of general anesthesia.
One minute before induction, baseline hemodynamics were recorded with standard ASA monitors as well as with the NICOM. Providers were given one 20ml syringe and one 10ml syringe for rescue if needed. As part of the induction, fentanyl (1-2mcg/kg) and any relaxant but succinylcholine and pancuronium were given. The 20ml syringe in both groups looked identical, appeared to be propofol but depending on the group they were randomized to, it represented either 2mg/kg of propofol (propofol group) or 0.75mg/kg of ketamine and 1.5mg/kg of propofol (ketofol group). The 10ml rescue syringe, if used, represented 1mg/kg of propofol (propofol group) or 0.25mg/kg of ketamine and 0.5mg/kg of propofol (ketofol group). Hemodynamics were recorded every minute for a total of 30 minutes post-induction. During this time, anesthesia was maintained with any volatile agent excluding nitrous oxide.
Primary analysis evaluated reductions in systolic blood pressure (SBP) of more than 20% from baseline. Secondary analysis evaluated amount of vasoactive agents used between the two groups as well as differences in pain and nausea/vomiting scores. Data was analyzed using an un-paired t-test, chi square or fisher's exact test as appropriate. A p-value of <0.05 was considered significant.
Results:
Comparison of the ketofol and propofol groups demonstrated a significant decrease of more than 20% in SBP from baseline in the propofol group at both 5 minutes (48.8%; 95% confidence interval [CI], 2.07 to 26.15, p=<0.001) and 10 minutes (67.4%; 95% CI, 1.21 to 8.75, p=<0.01). This was also significant for diastolic blood pressure and mean arterial pressure. At 30 minutes, there was no significant difference among the groups (p=0.39).
No significant differences were noted between groups with regard to preoperative vital signs, ASA status, or preoperative home medications. There was a trend towards higher vasoactive agent use in the propofol group as compared to the ketofol group during the 30 minute study period (p-value 0.07). No significant difference in case duration, intraoperative fluid administration, urine output, or estimated blood loss.
Conclusions:
A significant difference in systolic blood pressure, diastolic blood pressure and mean arterial pressure was noted between ketofol and propofol with ketofol demonstrating improved hemodynamics during induction of general anesthesia. Further study is needed to determine if this combination could be of benefit in high risk patients.