Still general, but I'll give points:
1) earning potential: potential is a relative word - for example, earn $1m, but live in NYC with $1m tiny condos with 1hr commutes each way or earn $500k and live in a small town or suburb with a 5000ft2 house on a 2 acre lake lot for $200k and no commute time, costs of general living (food, all non-medical insurances, etc.) are also relative; both countries have all of the above. It depends more on your costs of living and what your salary will give you in that area.
2) life and kids: you've had the opportunity to live on each side for a few years (assuming you have lived there for a few years/been born in Canada); you are probably one of the more knowledgeable individuals here on SDN for that. Again, location dependent: city vs. smaller town.
3) workload: centre dependent and relative again; similar situations seen in each country.
Canada and the US are more similar than some individuals would like it to be.
Things that may be different: insurance (CMPA reimbursement here in Ontario almost 90% returned; not sure about the US), benefits (eg. hours and holidays, appear to be more and less respectively in the US when I've searched for job openings there over the internet).
Think outside the medical arena - your personal life. Where do you have your family and friends at present; will they influence your decision in regard to proximity? Do you want to be somewhere warm year round? Do you like large cities/medium sized cities? Are you an outdoors person? Where would you feel more comfortable - Canada or US?
Questions to ponder, hope that gives more scope of what to look for in your decision.
