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Ive been using ringers or ns for years to dilute this. One of my partners pointed out just now the monograph says it must be sterile water.
Anyone any data on this?
Anyone any data on this?
Ive been using ringers or ns for years to dilute this. One of my partners pointed out just now the monograph says it must be sterile water.
Anyone any data on this?
Of course you can - we use LR for just about every IV and everything goes through it - fluid, blood, drugs, etc. We don't do the "you have to have a second IV because you have two antibiotics" nonsense.So it can be injected into an IV carrier delivering NS, LR or plasmalyte?
Why dilute it at all? Just have the patient sniff it.I think to be safe we may need to drain the blood and replace it with sterile water so we can be sure that cefazoline is not exposed to anything that is not recommended in the monogram. One problem though... when it reaches the tissue it might get in contact with things other than sterile water, so we need to figure out a way to avoid this violation of pharmacy policies.
This is the reason for the manufacturer's recommendation.Had a peds anesthesiologist tell me when I was a resident to reconstitute it in sterile water cause even that makes it slightly hypertonic, so reconstituting it in NS or LR makes it way too hypertonic. Seems reasonable for tiny veins but does it matter? Dunno
10% Calcium Chloride is even higher. And You don't have to push it down to isotonic. From what I recall if you can get it down to ~750mOsm/L you reduce the risk of thrombophlebitis.This is the reason for the manufacturer's recommendation.
I doubt it matters for the most part. Lots of the drugs we inject are anything but isotonic.
At the extreme end we've got 8.4% sodium bicarb, which has twice the osmolarity of 3% hypertonic saline, but I don't think anyone ever worries about giving that. You'd have to dilute a 50 mL amp of it in something like 350 mL of water to make it isotonic. Ain't nobody got time for that.
This is the reason for the manufacturer's recommendation.
I doubt it matters for the most part. Lots of the drugs we inject are anything but isotonic.
At the extreme end we've got 8.4% sodium bicarb, which has twice the osmolarity of 3% hypertonic saline, but I don't think anyone ever worries about giving that. You'd have to dilute a 50 mL amp of it in something like 350 mL of water to make it isotonic. Ain't nobody got time for that.
10% Calcium Chloride is even higher. And You don't have to push it down to isotonic. From what I recall if you can get it down to ~750mOsm/L you reduce the risk of thrombophlebitis.
Your blood or the patient's?I actually draw my ancef up in 10cc of blood so I know its in its destination environment. Prove me wrong. Lol
Why mix yourself when you can let the ancef pump in the chest do it for you!I inject the powder straight
Careful, the surgeon might start thinking it's cocaine and want a hit himself.Why dilute it at all? Just have the patient sniff it.
Careful, the surgeon might start thinking it's cocaine and want a hit himself.
Check "Gahart's INTRAVENOUS MEDICATIONS, A Handbook for Nurses and Health Professionals", it has a perfect table at the end of it titled "Solution Compatibility Chart", you may see your medication is listed and both NS and R or RL are Compatible.Ive been using ringers or ns for years to dilute this. One of my partners pointed out just now the monograph says it must be sterile water.
Anyone any data on this?