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This is not an anti-psychiatry motivated question, but a question I've genuinely been curious about. Antidepressant tachyphylaxis ("poop out") is well documented in the literature and usually the patients never regain their original sensitivity to the medication. This implies some permanent change to the brain (and that antidepressants are capable of permanently changing the brain). Does it thus follow and could one then conclude that they could permanently decrease sensitivity to serotonin?
I was surprised about this phenomenon because I've often been told in lectures that the effects of antidepressants completely reverse themselves after stopping the medication.
Anyone mind enlightening me a bit on this? Does my speculation make sense? It seems that other psych meds are able to cause adaptations that the brain does not fully reverse after stopping, so is that not possible with SSRIs? if not, then why.
Thanks!
I was surprised about this phenomenon because I've often been told in lectures that the effects of antidepressants completely reverse themselves after stopping the medication.
Anyone mind enlightening me a bit on this? Does my speculation make sense? It seems that other psych meds are able to cause adaptations that the brain does not fully reverse after stopping, so is that not possible with SSRIs? if not, then why.
Thanks!
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