Bunch of weirdos

[nimbus]

Awake Total Neuromuscular Blockade as Experienced by Anesthesiologist Volunteers

Accidental awareness during general anesthesia can be profoundly traumatizing, even in the absence of pain.1,2 Neuromuscular blocking drugs are implicated in almost all cases of accidental awareness, yet despite having been in clinical use for more than 70 years, the subjective experience of...

pubs.asahq.org

Apparently people like larger tidal volumes.

These are the same folks who videotaped paralyzed volunteers doing arithmetic with BIS<50.

Google Scholar

scholar.google.com

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[Dr. Rude]

Awake Total Neuromuscular Blockade as Experienced by Anesthesiologist Volunteers

Accidental awareness during general anesthesia can be profoundly traumatizing, even in the absence of pain.1,2 Neuromuscular blocking drugs are implicated in almost all cases of accidental awareness, yet despite having been in clinical use for more than 70 years, the subjective experience of...

pubs.asahq.org

Apparently people like larger tidal volumes.

These are the same folks who videotaped paralyzed volunteers doing arithmetic with BIS

Google Scholar

scholar.google.com

Pushing back the frontiers of knowledge. This was how NMBs were first studied in the 1950s. Anesthesia resident “volunteers”

 

[Ashers]

Subject 7 has good quotes.

I really wouldn't like to be a part of this.

 

[coffeebythelake]

"The IRB approval for this must have been wild"

 

[nimbus]

Subject 7 has good quotes.

I really wouldn't like to be a part of this.

They had quite a trip without any psychedelics.

 

[coffeebythelake]

Awake Total Neuromuscular Blockade as Experienced by Anesthesiologist Volunteers

Accidental awareness during general anesthesia can be profoundly traumatizing, even in the absence of pain.1,2 Neuromuscular blocking drugs are implicated in almost all cases of accidental awareness, yet despite having been in clinical use for more than 70 years, the subjective experience of...

pubs.asahq.org

Apparently people like larger tidal volumes.

These are the same folks who videotaped paralyzed volunteers doing arithmetic with BIS<50.

Google Scholar

scholar.google.com

Should we be doing more than 6-8cc/kg TV for healthy (non ARDS) patients??

 

[nimbus]

Should we be doing more than 6-8cc/kg TV for healthy (non ARDS) patients??

I was wondering the same for ICU patients. Maybe they would need less sedation.

 

[repititionition]

haven’t read the article yet but flow rate is likely more important than just tidal volume

 

[thinkorswim]

Are these nerds really talking about lung volumes and capacities?

I would be more along the lines of “holy **** this sucks, why the **** did I agree to do this?”

 

[Radetzky]

I was wondering the same for ICU patients. Maybe they would need less sedation.

☝

Should we be doing more than 6-8cc/kg TV for healthy (non ARDS) patients??

Yes

 

[nimbus]

Are these nerds really talking about lung volumes and capacities?

I would be more along the lines of “holy **** this sucks, why the **** did I agree to do this?”

Thus the title of the thread!

One of them said this with sux.

But then they agreed to try Roc lol.

 

[nimbus]

haven’t read the article yet but flow rate is likely more important than just tidal volume

Could be. Higher volumes require higher flows. Maybe that’s what they were craving.

From the article:

“However, if the ventilation was in any way inadequate, then dyspnea dominated the experience and, in some cases, caused marked distress. Subjects were ventilated manually via face mask, with initial tidal volumes of 7 to 10 ml/kg, at 10 to 12/min, targeting the lower end of normocapnia. Despite this, all subjects felt markedly short of breath and all signaled for much greater ventilation. The dyspnea did not resolve until tidal volumes were 12 to 15 ml/kg at 12 to 15/min. Previous studies have also described ongoing dyspnea at normal tidal volumes, in both volunteers and in chronically ventilated patients.4–6”

Assuming they were 70kg, they preferred minute ventilation of 10-15 liters/min. One could maintain normocapnia by rebreathing some of the exhaled gas although they may not like that either.

 

[DazedWanderer]

all subjects felt markedly short of breath and all signaled for much greater ventilation.

How did they signal? Did their pupils just dilate to the point you could see their tortured soul? Or did the researchers glove up and check sphincter tone at regular intervals?

 

[nimbus]

How did they signal? Did their pupils just dilate to the point you could see their tortured soul? Or did the researchers glove up and check sphincter tone at regular intervals?

They put a tourniquet on one arm so the isolated arm was not paralyzed. Then hand signals.

 

[Coffee PRN]

They put a tourniquet on one arm so the isolated arm was not paralyzed. Then hand signals.

That's actually pretty ****ing cool. I imagine they had a "safe signal" for reverse me the **** up right now.

 

[DesiredMemberName?]

That's actually pretty ****ing cool. I imagine they had a "safe signal" for reverse me the **** up right now.

probably this one: 🖕

 

[GassYous]

This is almost as crazy as when they were testing cocaine spinals on themselves back in the day