zoloft

[daisygirl]

Hi-
Could anyone post a link as to where I can find the mechanism of action of zoloft? I can't seem to find this information anywhere and the journal article that I need is not available at my school since my school started suscribing to the annals of pharmacotherapy in 1992 (the actual journal article I need was published in 1991). Thanks

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[Kalel]

Zoloft is an SSRI, or selective serotonin reuptake inhibitor.

http://www.rxlist.com/cgi/generic/sertral_cp.htm

 

[daisygirl]

Thanks Katel. However, I actually already know that information. What I need is a link where I can find out how Zoloft is an SSRI. Meaning- does it degrade some sort of enzyme, or does it bind to some sort of site at the the neuron where serotonin would normally get taken back in, etc....

 

[Kalel]

Go to this website and click on "click here to begin" to see a cartoon of how it works.
http://www.zoloft.com/index.asp?pageid=44

Part of it's mechanism is theorized to be linked to the down-regulation of serotonin receptors in addition to increasing the amount of serotonin within synapes. If you are looking for an exact explanation, I don't think that one doesn't exist. Levels of serotonin in the brain have been known to play a role in mood disorders for some time now, prozac was one of the first drugs designed with a molecular target in mind.

http://www.bentham.org/sample-issues/cmc9-8/spinks/spinks-ms.htm

 

[daisygirl]

Thanks so much Kalel!!!! The second link is exactly what I needed.