With all due respect to Sean Mackey, whose work I really enjoy reading, I'm doubtful that his patient population at Stanford is substantially similar to, say, a community pain doc in WV.
The problem I see with opiates that never seems to get discussed is the unreasonable expectation they set for patients when first prescribed. The degree of pain relief possible with opiates in the first few weeks is tremendous, unsustainable, and impossible to attain with any other passive therapy. Patients need to fully comprehend that.