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The Use of Ultrasound Reduces the Number of Failed Lumbar Punctures and Improves Ease of Performance of Lumbar Puncture in Obese Patients
Jason T. Nomura, Stephen J. Leech, Srikala Shenbagamurthi, Paul R. Sierzenski, Robert E. O'Connor, Melissa Bollinger, Margaret Humphrey and Jason A. Gukhool
Christiana Care Health System: Newark, DE
ABSTRACT
Background: While limited to case reports, ultrasound (US) has been described as a useful adjunct to lumbar puncture (LP). However, evidence demonstrating utility of US in LP in the emergency department is lacking. Objectives: We hypothesized that US-guided LP would increase success and ease of performing LP. Methods: This was an IRB-approved, randomized, prospective, blinded study conducted at an ED with an annual census of 92,000. A convenience sample of patients undergoing LP from January 2004 to December 2004 was enrolled. In addition to palpation landmarks (PL), all patients underwent US to identify the L3L4 or L4L5 interspinous space to establish the US landmark (UL). Patients were then randomized to have LP by PL or UL. Investigators identified the landmarks; however, operators were blinded to which landmark was to be used. Data collected included age, body mass index (BMI), number of attempts, ease of performance, and patient comfort on a 10-cm visual analog scale, procedure time, success, and traumatic LP, as defined by >400 RBCs in tube 1. Statistical analysis of data included 95% confidence interval (CI) and Student's t-test. Results: A total of 46 patients were enrolled. Twenty-two patients were randomized to PL and 24 to UL, with no baseline differences in age or BMI. Twelve patients had a BMI >30. Six of 22 attempts failed with PL vs. one of 24 with UL (p = 0.003). There was no difference in number of attempts, traumatic LPs, ease of procedure, patient comfort, or procedure length between groups. In 12 patients with a BMI >30, seven were randomized to PL, five to UL. Four of seven attempts failed with PL vs. 0/5 with UL (p = 0.03). Ease of procedure was significantly better with UL vs. PL, 2.66 (95% CI 2.53 to 2.79) vs. 6.86 (95% CI 6.38 to 7.34) (p = 0.01). There was no difference in number of attempts, traumatic LPs, patient comfort, or procedure length. Conclusions: The use of US for LP significantly reduced the number of failed LPs in all patients and significantly improved ease of procedure in patients with a BMI over 30.