Anyone have any idea where the data on chemo for T2N0 Anal margin/perianal skin comes from? NCCN recommends concurrent chemoRT. Seems to me you could consider XRT alone with electrons for anal margin if anal margin is positive for invasive disease.
have one right now as well. If it is hpv+, I would treat as anal cancer. Probably could get away with electrons of a lower dose of chemo rads, but wouldnt risk it.Anyone have any idea where the data on chemo for T2N0 Anal margin/perianal skin comes from? NCCN recommends concurrent chemoRT. Seems to me you could consider XRT alone with electrons for anal margin if anal margin is positive for invasive disease.
Just had the exact same thing. Had to bite the bullet for chemo rt. Seems like total overkill; was prob neglected hence how it got to a T2 with proximity to the canal. Quick question; why would p16 solidify this? Aren’t many pure skins p16+ anyway?have one right now as well. If it is hpv+, I would treat as anal cancer. Probably could get away with electrons of a lower dose of chemo rads, but wouldnt risk it.
I don’t think skin is typically hpv+. Agree that you have to bite the bullet here. If pt fails, I can see some very judgemental docs lining up to be experts…Just had the exact same thing. Had to bite the bullet for chemo rt. Seems like total overkill; was prob neglected hence how it got to a T2 with proximity to the canal. Quick question; why would p16 solidify this? Aren’t many pure skins p16+ anyway?
By that you mean HPV PCR positive or p16+? Lots of skin cancers are HPV negative yet P16 positive. Would be tough call to treat a clear skin cancer as anal cancer but i see your pointI don’t think skin is typically hpv+. Agree that you have to bite the bullet here. If pt fails, I can see some very judgemental docs lining up to be experts…
right thats exactly what i meant. have gotten into this boondoggle with H&N unknown primary huntsBy that you mean HPV PCR positive or p16+? Lots of skin cancers are HPV negative yet P16 positive. Would be tough call to treat a clear skin cancer as anal cancer but i see your point