Forgot to add this and I want my post to be evidenced based. Out of the few dozen I've tried I'd say less than 20% felt an actual benefit with Naltrexone for weight loss. So this is about what you'd see with a placebo. Also when I've done pubmed searches on it, I never saw anything highly convincing. From memory, and last time I checked was years ago, it was on the order of only a few subjects per test so they weren't highly convincing.
I've had success with Metformin and weight loss on the order of about 50%. Nice thing is it's cheap, safe, and good data that even off label could add to longevity. Only problems are side effects, but the one worrisome side effect is possible but unlikely B12 deficiency.
I always offer Metformin first to anyone who wants a GLP-1 agonist.