Let's compare, for example, two schools: one from Boston area and one from Philadelphia. It wouldn't be terribly difficult to find comparable schools (of course, if you were at Tufts, a four year program, in Boston, the year of lost salary would be zero and cost of tuition would be the primary marginal cost). Though most of the MD/MBA programs do not require prior work experience, most do seem to have some sort of internship/preceptorship/practicum requirements where you are, in some capacity, involved in an organization. Boston's opportunity for this seem to outweigh those in Philly: Boston Scientific, Genzyme, Biogen, MGH, Brigham and Womens, etc. What does Philly have? Brystol Myers Squibb, Hahnemann Hospital, Albert Einstein Hosp., any other? Clearly, I am biased towards Boston, but why wouldn't things like these matter when deciding between comparable schools? Also, if you go on after school to complete a residency, which a vast majority of MD/MBAs do, I believe the prestige of your school's business school begins to loose luster and your experience in residency begins to take more importance, sort of a testing grounds for your management qualifications.