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I took a leave of absence during my first year of medical school, because I wasn't sure if I wanted to be a doctor badly enough to endure the stress and depression I was experiencing. At this point, I'm not sure whether I want to go back or not. My question is, if I do decide to return to medical school, is my leave of absence going to prevent me from getting a decent residency--especially if I am honest about the reasons for my leave of absence?
If you return to medical school, get good grades / evaluations, and don't have any further leaves of absence, then yes you should do fine. If you try for a very competitive field you may run into some trouble. Many students take a leave of absence for all sorts of reasons, and as long as the issue is addressed, unlikely to recur, and you perform well in medical school, there should be no problem.
Exactly how open to be about your reasons is debatable. Personally, I suggest you tell the truth about the ambivalence about medicine -- as long as you can tell a convincing story that you've decided that medicine is what you want to do. Whether you want to talk about your depression is more debatable, as this is something that certainly could recur in residency and may make some programs shy away from you. You have the right to simply say you took a leave for personal reasons, and it's illegal (theoretically) for programs to inquire further -- however, when this happens to me I tend to assume the worst.