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Hey guys was hoping my colleages in GI could help with a question. I am in psych and had a question regarding some receptors and gut motility. I use mirtazipine quite often and as I am sure you know is a strong 5ht3 antagonist among other effects. I basically was trying to explain the side-effects and figure whether this would cause diarhea or consitpation potentially until I started to reason by other GI drugs then it made little sense.
Alosteron (which I dont think is availabe), a 5HT3 antagonist which I believe was available for IBS-D
V.
Drugs used in gastroparesis as motility agents such as
-reglan with strong 5ht3 antagnosim, with 5ht4 agonism and muscarnic effects
However, mirtazipine is also used in refractory gastroparesis patients?
Seems contradictory uses of the stuff. I understand mirtazpine and 5ht3 antagnoism being helpful for nausea/vomiting/appetite in gastroparesis but if it slows motility of the gi tract down, I cant see how that would be a benefit.
Alsofor reglan, I am guessing the 5ht4 agonism and pro muscarnic effects outweight the 5ht3 antagnoism effect on the gi tract for a net pro-kinetic activity.?
I see tons and tons of patients on reglan and a lot by the time they come to me have TD. I also use remeron a lot and often treat IBS so understanding this stuff is important. Until I realize I didnt understand it as well as I thought!
any help?
Alosteron (which I dont think is availabe), a 5HT3 antagonist which I believe was available for IBS-D
V.
Drugs used in gastroparesis as motility agents such as
-reglan with strong 5ht3 antagnosim, with 5ht4 agonism and muscarnic effects
However, mirtazipine is also used in refractory gastroparesis patients?
Seems contradictory uses of the stuff. I understand mirtazpine and 5ht3 antagnoism being helpful for nausea/vomiting/appetite in gastroparesis but if it slows motility of the gi tract down, I cant see how that would be a benefit.
Alsofor reglan, I am guessing the 5ht4 agonism and pro muscarnic effects outweight the 5ht3 antagnoism effect on the gi tract for a net pro-kinetic activity.?
I see tons and tons of patients on reglan and a lot by the time they come to me have TD. I also use remeron a lot and often treat IBS so understanding this stuff is important. Until I realize I didnt understand it as well as I thought!
any help?