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I understand COPD patients are mainly dependant on the PO2 levels for the respiratory drive and high flow oxygen supplementation can cause decreased stimulation of peripheral chemoreceptors leading to decreased ventilation.
I came across a statement saying high flow oxygen supplementation INCREASES the physiological dead space, leading to increased V/Q mismatch. How does this happen?
From my understanding, physiological dead space represents the alveoli that are ventilated but poorly perfused.
So if you increase oxygen supplementation, the pulmonary vessels should dilate, increasing the perfusion to these alveoli. Shouldn't that decrease V/Q mismatch?
Can someone explain, please?
I came across a statement saying high flow oxygen supplementation INCREASES the physiological dead space, leading to increased V/Q mismatch. How does this happen?
From my understanding, physiological dead space represents the alveoli that are ventilated but poorly perfused.
So if you increase oxygen supplementation, the pulmonary vessels should dilate, increasing the perfusion to these alveoli. Shouldn't that decrease V/Q mismatch?
Can someone explain, please?