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So I'm a bit confused on this question that appeared in Kaplan FL #3
A normal female rat injected with estradiol will respond by:
A. decreasing secretion of LH from the anterior pituitary.
B. increasing secretion of LH from the anterior pituitary.
C. decreasing secretion of GnRH from the hypothalamus.
D. increasing secretion of progesterone from the follicle.
My answer was A, since an increase in estradiol will cause a negative feedback effect on LH and FSH. However, the answer was B, and the reason they gave estrogen has a positive feedback effect on LH and FSH. I feel that's only true prior to the LH surge, but otherwise estradiol should have a negative feedback effect on LH and FSH. Can someone explain this to me?
A normal female rat injected with estradiol will respond by:
A. decreasing secretion of LH from the anterior pituitary.
B. increasing secretion of LH from the anterior pituitary.
C. decreasing secretion of GnRH from the hypothalamus.
D. increasing secretion of progesterone from the follicle.
My answer was A, since an increase in estradiol will cause a negative feedback effect on LH and FSH. However, the answer was B, and the reason they gave estrogen has a positive feedback effect on LH and FSH. I feel that's only true prior to the LH surge, but otherwise estradiol should have a negative feedback effect on LH and FSH. Can someone explain this to me?