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Hi,
I took the second Medicine NBME exam and had some more questions that I was hoping someone could help me out with. Thanks in advance.
1. Overweight 65 year old male who smokes 1 pack per day. Brother died of CVA and parents died at 40. BP is 150/102, he has grade 2 hypertensive retinopathy, and PMI is displaced 2cm laterally. Which lab test is best for initial assessment?
a. Plasma renin
b. serum aldosterone
c. Serum creatinine
d. urine metanephrine
e. urinary sodium/creatinine ratio
look for kidney damage, as there is already evidence of other organ damage. They give you his weight, age, and smoking status to make the case for essential HTN vs secondary.
2. 47 year old women with 10 week history of cough. Had a DVT treated with warfarin 6 months ago. Non-smoker. Examination has no abnormalities. Chest X-ray shows 3-cm peripheral lesion. What is the diagnosis?
a. Adenocarcinoma
b. bronchiolitis obliterans with organizing pneumonia
c. chronic idiopathic pulmonary fibrosis
d. pneumoconiosis
e. sarcoidosis
f. small cell cancer
g. squamous cell cancer
h. TB
Female, non-smoker, peripheral lesion=adenocarcinoma
Guessing this one is adenocarcinoma but I didn't go with that one originally because age was 47
3. 37 year old female with 6 week history of puffy eyes and swelling of her legs. Heavy bleeding with menses and increasing pain in arms and legs for the past 6 months. Menses are regular 28 days. No PMH. Takes a multivitamin and calcium carbonate. Had 12 pound weight gain in last 3 months. BMI is 25. Pulse 55, BP 100/70. Exam shows periorbital edema, distant heart sounds, mild tenderness in upper/lower extremities, 2+ edema to calves. Pelvic exam normal. Labs show Na 130, K 3.8, BUN 10, Cr 1, Cholesterol 300, CK 130. What is next best step in diagnosis?
a. HIV
b. CA 125 concentration
c. Serum FSH concentration
d. Serum Glucose
e. Serum TSH
f. Muscle biopsy
Hypothyroid? Yep. Weight gain, low pulse/BP, periorbital and pretibial myxedema.
4. 62 year old women with 2 day history of confusion. Has HTN and DM2. Takes ramirpril and glipizide. Oriented to person but not time or place. Physical exam including neuro is normal. Hematocrit 24%, WBC 3400 (65% neutrophils, 35% lymphs), Ca 13.0, Cr 2.0, Total Protein 9.5, Albumin 4.5. What is next step in management.
a. CT scan of head
b. cefepime
c. IV normal saline
d. lumbar puncture
e. hemodialysis
Treatment for severe, symptomatic hypercalcemia is IV NS.
5. 22 year old man 2 days after closed head injury in MVA. CT scan on admission normal. Received D5 with .45% normal saline. Mental status last 12 hours has been normal. Urine output 50ml/hr last 24 hours. Physical is normal. Labs show sodium 120 and urine osmolality 340. What is next step?
a. fluid restriction
b. CT head
c. ADH
d. bolus normal saline
e. bolus 3% saline
I put 3% because it was a head injury and thought you didn't want to risk cerebral edema but I'm guessing they were looking for fluid restriction?
3% is used for severe hyponatremia manifesting with risks of herniation including altered mental status and seizures. In his case, his mental status is fine, CT is normal, kidney function is good base on urine output, so just water restrict.
6. 52 year old women with polyuria and polydipsia. Takes HCTZ for HTN for 8 years; current BP 120/80. Labs show Na 148 and Cl 110. Water deprivation test done. Over 5 hours urine osmolality increases from 200,250,300,380,400,400 and serum 285, 288, 290, 295, 298, 300. Given desmopressin and urine osm increases to 1000. What is cause of polyuria?
a. HZTZ induced nephrogenic DI
b. Central DI
c. idiopathic neprogenic DI
d. primary polydipsia
e. salt-losing nephropathy
I'm guessing the answer is central DI but I wasn't sure because the urine osm was increasing. I always thought it had to increase less than 50 for it to be considered DI.
The rapid inc in urine osmolality post ADH administration suggests central DI.
7. Lady weeding and fertilizing and develops rash on face, neck and hands. She used sunscreen but no insect repellant. Was scratched by multiple rose bushes. Has bright red papules, vesicles, and bulla, some in linear arrangement on forearms, face, and neck. Wrist has oozing vesicles. What caused this?
a. fertilizer
b. weeds
c. rose bush
d. sun
e. insects
linear vesicles=contact dermatitis, probably from brushing up against weeds. Rose bush sporothrix causes an ulcer and spreading lymphangitis