O blood group mothers have IgM? or IgG?

[teehees]

First Aid says O blood group people have IgM.

Uworld says they have IgG (usually) QID 8261

Go with uworld I guess? Their reference doesnt mention anything on it

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[aspiringmd1015]

most have igM, some can have igG, i think its in goljan, but UW is usually the king

 

[teehees]

yep Uworld is saying Most IgG

 

[teehees]

Another discrepancy:

QID 224 IGF 1 acting via JAK-STAT. First aid states insulin receptor kinases work via MAP Kinase. Just noticed it by chance when I was kicking myself for overcomplicating an easy question.

Probably not high yield enough for anyone to care about

 

[zhopv10]

Another discrepancy:

QID 224 IGF 1 acting via JAK-STAT. First aid states insulin receptor kinases work via MAP Kinase. Just noticed it by chance when I was kicking myself for overcomplicating an easy question.

Probably not high yield enough for anyone to care about

Growth hormone goes through Jak/stat (primarily), and IGF-1 goes through receptor tyrosine kinase---> MAP (it is a really strong activator of Akt which is pro mitosis and inhibits apoptosis). http://www.ncbi.nlm.nih.gov/m/pubmed/8548048/
http://www.ncbi.nlm.nih.gov/gene/3480
http://www.genecopoeia.com/product/search/pathway/h_longevityPathway.jpg

Basically: GH activates jak/stat signally (specifically in the liver) initiating transcription for IGF-1---> IGF-1 receptor (tyrosine kinase and it actually can activate insulin receptor too if I remember right) which activates the MAP pathway initiating growth.

This is in line with my notes from the uworld questions I've had in it.


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[recycledpaper]

Growth factors are intrinsic tyrosine kinase. Are you thinking of growth hormone for JAK-STAT?

 

[zhopv10]

Growth factors are intrinsic tyrosine kinase. Are you thinking of growth hormone for JAK-STAT?

Doh! Ya sorry typo, thanks for catching that! (Corrected in original post for clarity)


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[teehees]

ah yep I re-read what uworld was trying to say and it looks like it was actually in line with what you wrote. Thanks again

Looks like its just the O blood group difference that exists