Because herpes simply 1 buds through the nuclear membrane, it it sensitive to lipid solvents.
wiki: "Symptoms resulting from primary infection with HSV are usually more severe than subsequent outbreaks, as the body has not had a chance to produce antibodies."
It is also common knowledge (at least in my neck of the woods) that the first herpes outbreak is the worst (though all old asda papers say that the first infection is subclinical...so i guess when it becomes CLINICAL the first time is the worst.)
With all due regards to the explanation here ,
HSV 1 , primary sites affected , is not just oral /peri-oral , and thus the 3rd option , and acc to shafers , its primary lesions which are mostly misdiagnosed, and hence subclinical or may be just with a range of prodromal symptoms , masking the disease .
imo , 3rd option is the ans for 1st q
Pls correct me ![/QUOTE]
I am not sure about this, this primary location for HSV type I is the oral cavity, note the question say most are found around the mouth and oral cavity which is very true, You are correct in saying that it can occur in other places: second most common for HSV type I is the genital followed by the fingers(herpetic witlow) but by far 96% of outbreaks with occur around or in the oral cavity. Second the primary lesions outbreak of HSV is called herpetic gingivostomatitist, which is very painful, Lesions is a key to this answer, subclinical infection which is most common when first infected with HSV will have no lesions(hence subclinical) So when the question talks about primary LESIONS, they are referring to herpetic gingivostomatitist, which would be very painful, alot worse than recurrent herpetic ulcers on the hard palate or recurrent herpes labialis. Most primary infections are subclinical and they pt has no idea they have been infected, until they get the secondary infections. Also a primary infection is not the first time you see it clinically, It is when you first contract the virus, There are some general things that follow after primary infection: your body fights off infection produces antibodies which will elimate the virus or in the case of HSV it doesn't because the virus lives in the ganglion, 2.you body can't fight the infection completely and your get lesions and symptoms that develop, which are primary lesions for the few people that develop primary lesions, you will know b/c they will be in your office complaining of fire in their mouth. Also when you are talking about prodromal symptoms, this is refering to secondary lesions, there is no way to have prodromal symptoms of a primary lesion. Since primary lesions occur at the time of contraction of the virus the word prodromal means that you are getting symptoms before the actual clinical visualization of a lesion, and since primary lesions occur at the time of contraction you cant have symptoms before you actually get the virus, so prodromal makes absolutely no sense.
For reference this is information is from Dr. Douglas Damm, Dr. Brad Neville, and Dr. Dean White who wrote the text book "Oral & Maxillofacial Pathology" and "Color Atlas of Clinical Oral Pathology " and also run the oral pathology lab at the University of Kentucky.
The key to this test and any test is to pay attention to what the question is asking, a single word can dramatically change the answer.
