1) Neurologic Signs or Symptoms or Clinical Suspicion of Cauda Equina, Cord Compression, or Epidural Abscess/Discitis require a stat MRI of the spine. This is *especially* important in patients patients who have known cancer, known cancer with bony mets, or clinically suspected discitis/epidural abscess. It is disasterous to ignore, in these patients, symptoms of new onset back pain or worsening back pain but WITHOUT neurologic *signs* on physical exam at this time. The reason it is so important is that once neurologic signs are found then it usually too late to reverse these neurologic signs even if the proper treatment is given (ie steriods, radiation, emergent neurosurgery).
2) Acute Stroke. Althought one may argue that every patient should get an MRI, the clinical reality is that patients would miss their 3 hour window after persenting to the ER and getting worked up, because the patient first needs a head CT to exclude a hemorragic infarct or large infarct (which would be contraindications to TPA). Also, neurologists would argue is that stroke is a clinical diagnosis. If the head CT does not contraindicate TPA therapy and the person is in the 3 hour window it is probably best to give the TPA as soon as clinically feasible. The less time the brain is hypoxic/ischemia the better.
3) Acute hip fracture in the elderly patient in whom plain films are negative but the clinical suspicion of hip fracture is high and who are surgical candidates.
4) Possibly Trauma (ie high speed mva, fell off a high story building) with ? neurologic signs in whom there is not fx/dislocation of c/t/l spine who will/may need urgent but not emergent surgery for other issues such as general/trauma abd surgery or extremity surgery by ortho/plastics.
5) Soft tissue infections are NOT an indication for stat MRI. CT and/or Ultrasound can do a good job of telling if there is a drainable fluid collection/abscess vs inflammatory/infectious changes.
That is all I can think of at this time. I believe many other thingse can wait until the morning or the next day or be imaged with another modality. (Please, be reasonable).