First, it seems that the overwhelming majority of successful Drexel post-baccs are those that go to Drexel Med. Clearly there is nothing wrong with this, but my point here is I feel that Drexel's primary means to med school is giving you a slightly better chance at getting into DCOM if you meet a certain GPA requirement...and even then it's no guarantee. This is purely anecdotal, but if you do "well" at Penn you will be in a much more advantageous position once applying. Second, the administrative aspect IMO cannot be compared. I never heard from Drexel post bacc after applying very very early and late in the spring i called them to inquire and I was told i was accepted and they were "waiting" to hear from me....which really really bothered me. On the contrary, Penn's post-bacc program is highly organized, very professional (interview/tour is like a med school interview day only more laid back), and the advising is top-rate. Lastly, yes it is harder. The basic sciences are curved to a C+/B- and in an entire class of post-baccs this may become problematic. That being said, med schools seem to realize the nature of Penn and the post-bacc program and many of the requirements for linkages require a GPA between 3.2-3.4. Also, the classes are all at night so the program does accommodate working students. IMO, penn is the better option unless you feel very strongly for drexel and drexel med. I have known people to work hard in the drexel program and they get into DCOM and it appears like a very smooth transition and great opportunity....however, for most of us, i feel putting yourself in a more objective and positive light towards a wide array of schools is better in the long run. good luck