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I have to write a short write-up on a patient, and was curious, if a patient says he is diagnosed with depression, but he has a lot of medical conditions (diabetes, COPD, CHF, cataracts, renal failure, kidney stones) and is on several meds (none of which are known to cause depression), does he fit the criteriea for depression? One of the criteriea for depression is that "symptoms are not due to the direct physiologic effects of a substance or a general medical conditions." Having all those illnesses for a long time will probably make you deppressed, but does it constitute a "direct physiologic effect?"