Critical care question

[ollaguna]

Anyone familiar with argatroban? I presented a case of HIT, including the use of argatroban, but didn't find any info on when to DC the medication? When do you stop anticoagulating the patient? I'm figure the answer has something to so with the half life of heparin induced IgG's?

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[Winged Scapula]

Originally posted by ollaguna
Anyone familiar with argatroban? I presented a case of HIT, including the use of argatroban, but didn't find any info on when to DC the medication? When do you stop anticoagulating the patient? I'm figure the answer has something to so with the half life of heparin induced IgG's?

Depends on why they were on heparin in the first place as to how they they need to be anticoagulated. But in general, my experience is that we leave someone on argatroban until the PTT is 2-3 times normal (or INR is super-therapeutic) - this can take several days and then switch them to oral anticoag if they can tolerate it/ready to take PO.