- Joined
- May 12, 2013
- Messages
- 212
- Reaction score
- 37
Is there a descriptive explanation on how antibodies to cardiolipin (a phospholipid in mitochondria?) cause thrombosis?
Is it because when there is endothelial damage and von-willebrand factor is exposed on the endothelial surface of the blood vessel, in which glycoprotein 1B usually helps platelets adhere to vWBF on the vessel endothelium - but in APS, the aCLs, specifically B2GP1 enhances this process?
I'm not connecting the dots between cardiolipin, and the anticardiolipin antibodies with how the clot initially forms?
Is it because when there is endothelial damage and von-willebrand factor is exposed on the endothelial surface of the blood vessel, in which glycoprotein 1B usually helps platelets adhere to vWBF on the vessel endothelium - but in APS, the aCLs, specifically B2GP1 enhances this process?
I'm not connecting the dots between cardiolipin, and the anticardiolipin antibodies with how the clot initially forms?
