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I was not familiar with this risk. Doing a lit search right now. What’s the deal with it, especially compared to other opioids (not methadone)?
Butrans- cardiac arrhythmia risk?
- Thread starter Taus
- Start date
High doses, QTc prolonged.
www.ncbi.nlm.nih.gov
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Ventricular arrhythmia or cardiac arrest was reported in 1.8% of buprenorphine cases compared with 11.6% of methadone cases. Similarly, 0.3% of buprenorphine cases reported QTc prolongation/torsade de pointes compared with 2.6% of methadone cases. Torsade de pointes was reported in 0.1% of buprenorphine cases compared with 1.7% of methadone cases.
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Generally not the sole agent involved.
Generally seems to require twice the maximum dosage of Butrans patches, so likely not a problem for pain physicians unless using very high dose Belbuca or Suboxone.
Arrhythmia Associated with Buprenorphine and Methadone Reported to the Food and Drug Administration
To assess the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, QTc prolongation, or torsade de pointes to the US Food and Drug Administration (FDA) between buprenorphine and methadone.Retrospective pharmacoepidemiologic ...
www.ncbi.nlm.nih.gov
Ventricular arrhythmia or cardiac arrest was reported in 1.8% of buprenorphine cases compared with 11.6% of methadone cases. Similarly, 0.3% of buprenorphine cases reported QTc prolongation/torsade de pointes compared with 2.6% of methadone cases. Torsade de pointes was reported in 0.1% of buprenorphine cases compared with 1.7% of methadone cases.
"
Generally not the sole agent involved.
Generally seems to require twice the maximum dosage of Butrans patches, so likely not a problem for pain physicians unless using very high dose Belbuca or Suboxone.
