USMLE AFP in spina bifida and other neural tube defects (FA & publications discrepancy/confusion)

[Tyler D]

FA 14 Pg 445 says that meningocele has a Normal AFP level.
Several publications mention that AFP is high in "Open" Spina Bifida and in Anencephaly.
Which types of Spina Bifida are termed Open ?
Rachischisis ?

What is the AFP level in Spina Bifida oculta, Meningocele and Meningomyelocele and in Rachischisis ?

Thanks.

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[EazyE1907]

spina bifida has a normal AFP. Meningocoele and myelomeningocoele has an elevated AFP as does anencephaly. i wouldn't look into it too much i don't think the different subtypes of these disorders are high yield. just know what i stated above and remember that maternal folic acid supplementation BEFORE pregnancy and during is important for the neural tube to close.

 

[notbobtrustme]

never saw a distinction between those conditions between AFP values and I took like 3 or 4 NBMEs + shelves + Uworld + Rx and the real deal.

probably super low yield and not worth expending that much time on. EazyE1907 has the right idea. The most important thing regarding spina bifida + assoc conditions is folate supplementation before pregnancy.

 

[Tyler D]

Thanks !
You mentioned that Meningocele and Meningo-myelocele has elevated AFP.
FA mentions that Meningocele has Normal AFP.
So FA would be wrong on that one then ?