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- Jan 24, 2017
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How essential is it to know that 11-deoxycortisol is derived from 17-hydroxyprogesterone via 21-hydroxylase or that 11-deoxycorticosterone is derived from corticosterone, etc.? I understand it's important to know that a deficiency in 11beta hydroxylase will result in decreased aldosterone (but weak aldosterone action due to 11-deoxycorticosterone) and cortisol, and that 21 hydroxylase will result in decreased cortisol and aldosterone, 17 alpha decreased cortisol, and sex steroids. But do I really need to know the ins and outs of this pathway minus clinical presentations?