Ok here we go Dr. YMP, i thought about this long and hard. you have a very valid point!!! Now let me put it to you this way, say you do a serum calcium test and its normal than what are you gonna do. Fine you ruled out Hyperparathyroidism(Brown Tumour) Now you got three left!!! Histolgically the main components are the same, MULTNUCLEATED GIANT CELLS!!! The difference are what other type of cells, tissue, vascular etc. etc.
Giant cell Granuloma - has ovoid spindle shaped mesenchymal cells, stroma is loosely arranged and edematous, or it could be quite cellular, areas of erythrocyte extravasation and hemosiderin deposition are prominent
Cherubism - vascular fibrous tissue, stroma in cherubism often tends to be more loosely arranged than seen in giant cell granuloma, some cases reveals eosinophillic cufflike deposits surrounding small blood vessels, the eosinophillic cuffing appears to be specefic for cherubism
Aneurysmal Bone Cyst - space filled with unclotted blood surrounded by cellular fibrolastic tissue containing multinucleated giant cells and trabeculae of osteid, wall contains an unusual lacelike pattern of calcification that is uncommon in other intraosseous lesions
These H/P features are just a few i have mentioned. I hope this helps. When are you giving your EE, where are you from and where did you do your dentistry???
You are absolutely right... The histological difference you had mentioned are looking good
Giant cell Granuloma:
"In most instances, the microscopic findings have guided the investigators into diagnosis of giant cell tumor rather than Giant cell granuloma"
(Ref: Sheffar; Fourth Edition; Page: 147)
Cheburism:
Histopathology: "The lesions are virtually indistinguishable from the giant cell granuloma of the jaws"
(Ref: Sheffar; Fourth Edition; Page: 701)
Hyperparathyrodism
These foci are indistinguishable from giant-cell granulomas
of the jaws. Unlike the latter, there are characteristic changes in
blood chemistry
(Ref: Cawson; 7th Edition; Page 160)
• Hyperparathyroidism. Histologically indistinguishable from giant
cell granuloma but serum calcium levels are raised
• Cherubism. May be indistinguishable from giant-cell granuloma
histologically, but lesions are symmetrical, near the angles of the
mandible
• Giant-cell tumour (osteoclastoma). Aggressive tumour of long
bones. Broadly similar histologically to giant-cell granuloma but a
distinct entity in terms of behaviour
• Aneurysmal bone cysts may contain many giant cells but consist
predominantly of multiple blood-filled spaces
(Ref: Cawson; 7th Edition; Page 141)
So, what i wonna say is, The histological differences may or may not be find, As histological difference you mentioned is even there in book but in all cases book says may be found... So that doent help in Definative diagnosis.