It counts as an exam fail for the total attempts (and there's some state-based rule about when fails can be "forgiven"), but no, a first time failure is not a big deal. There is someone on this board who was screwed over because this person failed twice under the old standard, then failed under the new standard for the first time years later, which the state counted as 3 attempts not 1. I wish that would have been counted as 1.
@CNB
I fully disagree with the idea that old pharmacists couldn't pass the current exam. Not even with the BCPS (where if you can pass that, you should pass the new standard NAPLEX drunk), but if you are in reasonable practice, you should be able to cold turkey the exam besides a quick (as in a hour or two) review with those calculations on the exam that no one does in practice like Class III balance, aliquot, and MEq/MOsM. Now, those people who cheated their way through school and passed on a good day, yeah they still suck and we still have them in practice and couldn't consistently pass the exam, but even administrative pharmacists should be able to pass this on the basis of bad memory, it is that easy. This is a minimum competency exam, I want everyone to practice better than just passable here. Although I will acknowledge that there are observably idiotic pharmacists out there, I don't think you have the perspective where classes were such that your worst students were reasonably competent such that the curriculum was universally thought of as a joke as well as the licensing exams. It sucks where you are in a program where they admit people that it wasn't a obvious certainty at admission that they would pass the NAPLEX (although there are schools that admit for things that have nothing to do with pharmacy which they deserve what they get).
I kind of wish that the minimum competency standard would be the PEBC (Canadian) exam, because once upon a time, the Canadians would take the NAPLEX when it was NABPLEX, but broke off and made their own exam because the NABPLEX was too substandard for themselves. That's how low a regard others have for the exam.