At most programs two things really stand out about 1st and 2nd year grades...those that are terrible and those that are outstanding. And with that being said, the typical 3.2-3.7 GPA is relatively equal. Each school is different, so unless you failed or got straight A's, then it truly means very little.
It is always a positive thing to look and see what 3rd year rotations you recieved honors on...but also, this is likely a subjective measurement.
When "grading candidates" we weigh the interview highly, and also read any letters that are available. Your personal statement will also be read. USMLE/COMLEX scores are taken into consideration, but only really matter when they are exceptionally poor or outstanding.