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Having trouble telling these two apart in a question stem.
Both present as precipitously dropping Hgb w/ reticulocytosis in a sickle cell disease patient. I just had a UWorld Q where splenic sequestration presented with splenomegaly, low haptoglobin, and jaundice -- all of which I would also assume in a hyperhemolytic crisis.
All I can think of are the following two points:
-Hyperhemolysis is more likely in older children, as the spleen is probably too auto-infarcted after the first few years of life to sequestrate
-Most hyperhemolytic crises seem to be related to transfusion, according to a quick literature search? Not too sure about this one...
Am I missing anything here, or is that really all there is to reliably tell the two apart?
Both present as precipitously dropping Hgb w/ reticulocytosis in a sickle cell disease patient. I just had a UWorld Q where splenic sequestration presented with splenomegaly, low haptoglobin, and jaundice -- all of which I would also assume in a hyperhemolytic crisis.
All I can think of are the following two points:
-Hyperhemolysis is more likely in older children, as the spleen is probably too auto-infarcted after the first few years of life to sequestrate
-Most hyperhemolytic crises seem to be related to transfusion, according to a quick literature search? Not too sure about this one...
Am I missing anything here, or is that really all there is to reliably tell the two apart?
