Note: I'm not involved in residencies or residency selection whatsoever. I don't even work professionally. I'm just a lowly P4 student.
If I were interviewing you, I'd absolutely hold your presentation against you if you did a poor job. It's your job to prepare. Residency itself is insanely rigorous, but you can't sacrifice the quality of your work there. Also, you've gotten this far. If you don't know what questions to expect for your presentation or what the data suggest on the topic you're presenting, that is really telling about your understanding of the significance of what you're presenting. AND that's the topic you chose to present on!
But I definitely empathize. There are some crazy requirements at some of these programs. One of my classmates had to essentially put together a portfolio for submission a week prior to her interview that included a clinical presentation slide deck, a non-pharmacy related presentation slide deck, two drug information questions and responses, a journal club handout, and a topic discussion handout. She essentially had a two week turnaround on it all. That seemed like overkill to me. Not to mention all the other time commitments you already mentioned. And on top of it all, the huge expense and stress of applying and traveling for interviews is really off-putting. There's no denying the financial stress involved. I really wish the pharmacy profession made more of an effort to make this cost effective for students.
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