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Could the AHCA cure patients of their centralized pain syndromes?
Could the AHCA cure patients of their centralized pain syndromes?
Could the AHCA cure patients of their centralized pain syndromes?
I don't buy fibromyalgia is simply a manifestation of depression, although depression is associated with fibromyalgia. There are physical changes that are not explainable by depression. We do not have enough information to accurately characterize FMS as a specific disease, but also do not have evidence it is solely a psychological condition.
NAIL BED CAPILLARY DIFFERENCES IN THOSE WITH FMS
Quantitative analysis of nailfold capillary morphology in patients with fibromyalgia. - PubMed - NCBI
CUTANEOUS AV SHUNTS IN FMS PATIENTS
Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (AVS) in the palmar glabrous skin of fibromyalgia patients: implicat... - PubMed - NCBI
CEREBRAL BLOOD FLOW DIFFERENCES IN FMS PATIENTS
Cerebral blood flow dynamics during pain processing in patients with fibromyalgia syndrome. - PubMed - NCBI
IL-8 HIGHER IN FMS PATIENTS
Arterial stiffness and proinflammatory cytokines in fibromyalgia syndrome. - PubMed - NCBI
SKIN MAST CELL CONCENTRATION IS MUCH GREATER IN FMS PATIENTS
Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients. - PubMed - NCBI
PAIN RELATED TO SYMPATHETIC ACTIVITY IN FMS
Relationship between sympathetic activity and pain intensity in fibromyalgia. - PubMed - NCBI
Pain Research and Treatment
Volume 2012 (2012), Article ID 486590, 9 pages
http://dx.doi.org/10.1155/2012/486590
Review Article
Fibromyalgia and Depression
Richard H. Gracely,1 Marta Ceko,2,3 and M. Catherine Bushnell2,4,5
1Center for Neurosensory Disorders, University of North Carolina, CBNo.7280, 3330 Thurston Building, Chapel Hill, NC 27599, USA
2Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada
3Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada
4Department of Anesthesia, McGill University, Montreal, QC, Canada
5Department of Neurology & Neurosurgery, McGill University, Montreal, QC, Canada
Fibromyalgia and depression might represent two manifestations of affective spectrum disorder. They share similar pathophysiology and are largely targeted by the same drugs with dual action on serotoninergic and noradrenergic systems. Here, we review evidence for genetic and environmental factors that predispose, precipitate, and perpetuate fibromyalgia and depression and include laboratory findings on the role of depression in fibromyalgia. Further, we comment on several aspects of fibromyalgia which support the development of reactive depression, substantially more so than in other chronic pain syndromes. However, while sharing many features with depression, fibromyalgia is associated with somatic comorbidities and absolutely defined by fluctuating spontaneous widespread pain. Fibromyalgia may, therefore, be more appropriately grouped together with other functional pain disorders, while psychologically distressed subgroups grouped additionally or solely with affective spectrum disorders.
REST OF ARTICLE HERE: https://www.hindawi.com/journals/prt/2012/486590/
maybe that is a secondary effect of the depression?
more likely represents a real finding in some patients but only manifests itself - as chronic pain - in someone who has predisposing depression...
Thanks for posting those links! Have you had any success using Clonidine (due to the sympathetic component)?I don't buy fibromyalgia is simply a manifestation of depression, although depression is associated with fibromyalgia. There are physical changes that are not explainable by depression. We do not have enough information to accurately characterize FMS as a specific disease, but also do not have evidence it is solely a psychological condition.
NAIL BED CAPILLARY DIFFERENCES IN THOSE WITH FMS
Quantitative analysis of nailfold capillary morphology in patients with fibromyalgia. - PubMed - NCBI
CUTANEOUS AV SHUNTS IN FMS PATIENTS
Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (AVS) in the palmar glabrous skin of fibromyalgia patients: implicat... - PubMed - NCBI
CEREBRAL BLOOD FLOW DIFFERENCES IN FMS PATIENTS
Cerebral blood flow dynamics during pain processing in patients with fibromyalgia syndrome. - PubMed - NCBI
IL-8 HIGHER IN FMS PATIENTS
Arterial stiffness and proinflammatory cytokines in fibromyalgia syndrome. - PubMed - NCBI
SKIN MAST CELL CONCENTRATION IS MUCH GREATER IN FMS PATIENTS
Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients. - PubMed - NCBI
PAIN RELATED TO SYMPATHETIC ACTIVITY IN FMS
Relationship between sympathetic activity and pain intensity in fibromyalgia. - PubMed - NCBI
Never met a SFN neuropathy patient that did not have same psych overlay as FMS. Treatment seems same. Neuropathics, no narcs.You all do know that skin biopsies show dermal changes in fibromyalgia patients similar to those seen in small fiber neuropathy