Hey,
FA mentions that ACh/adenosine decreases the rate of diastolic depolarization and reduce heart rate. When they write it like they do (ACh/adenosine) I get the impression that they mean that even adenosine causes a reduced heart rate. But that's not the case, right?
ACh binding to its receptor in this case causes activation of an inhibitory alpha-subunit in the G-protein, causing inactivation of adenylate cyclase and thus decreased amount of cAMP. So the less adenosine the less the heart rate is, with more Ach causing this greater lessening.
Or did I miss something?
FA mentions that ACh/adenosine decreases the rate of diastolic depolarization and reduce heart rate. When they write it like they do (ACh/adenosine) I get the impression that they mean that even adenosine causes a reduced heart rate. But that's not the case, right?
ACh binding to its receptor in this case causes activation of an inhibitory alpha-subunit in the G-protein, causing inactivation of adenylate cyclase and thus decreased amount of cAMP. So the less adenosine the less the heart rate is, with more Ach causing this greater lessening.
Or did I miss something?