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Discussed this case from Case Files Critical Care with my attending today (pasted if you feel like reading, but if tldr: asthma exacerbation, young person).
A 35-year-old woman with persistent severe asthma is being seen in the ED. On a previous admission, she required mechanical ventilation and was transferred to the intensive care unit (ICU) for treatment of an asthmatic exacerbation. For the past week, she has increased her use of a β2 agonist as rescue medication by 6 to 8 times normal, and has nighttime exacerbations every evening. On physical examination she is in acute respiratory distress with nasal flaring and a quiet chest with very distant wheezing. An ABG drawn on 30% oxygen shows a pH of 7.35, PaCO2 42 mm Hg, PaO2 89 mm Hg, and bicarbonate (HCO3) of 23 mEq/L. Peak expiratory flow rates are all below 40% of the patient's predicted range. Her respiratory rate is 30 breaths/minute, heart rate is 110 beats/minute and regular, and blood pressure is 150/78 mm Hg with a pulsus paradoxus of 10 mm Hg.
My question is regarding the appropriate initial settings for this patient. The Owen book recommends:
§ AC/VC mode
§ VT: 8 mL/kg IBW
§ RR: 10-14
§ I:E ratio: 1:3
§ PEEP: Start with 0.
She says the 6 mL/kg IBW is better these days, with higher RR and PEEP 5.
However, The Ventilator Book asserts that lower VT can lead to air trapping/worsening hyperinflation. Also states that applied PEEP will worsen hyperinflation.
A 35-year-old woman with persistent severe asthma is being seen in the ED. On a previous admission, she required mechanical ventilation and was transferred to the intensive care unit (ICU) for treatment of an asthmatic exacerbation. For the past week, she has increased her use of a β2 agonist as rescue medication by 6 to 8 times normal, and has nighttime exacerbations every evening. On physical examination she is in acute respiratory distress with nasal flaring and a quiet chest with very distant wheezing. An ABG drawn on 30% oxygen shows a pH of 7.35, PaCO2 42 mm Hg, PaO2 89 mm Hg, and bicarbonate (HCO3) of 23 mEq/L. Peak expiratory flow rates are all below 40% of the patient's predicted range. Her respiratory rate is 30 breaths/minute, heart rate is 110 beats/minute and regular, and blood pressure is 150/78 mm Hg with a pulsus paradoxus of 10 mm Hg.
My question is regarding the appropriate initial settings for this patient. The Owen book recommends:
§ AC/VC mode
§ VT: 8 mL/kg IBW
§ RR: 10-14
§ I:E ratio: 1:3
§ PEEP: Start with 0.
She says the 6 mL/kg IBW is better these days, with higher RR and PEEP 5.
However, The Ventilator Book asserts that lower VT can lead to air trapping/worsening hyperinflation. Also states that applied PEEP will worsen hyperinflation.