Patient stated they took 70 hydrocodone/APAP 10/500's.
4 hours post ingestion, serum apap = 105ug/ml, resp rate 20, A/O x 3, ast24/alt18.
8 hours, APAP decreased to 63, pt still stable.
24 hours, pt still stable, ast36/alt36, APAP levels not obtained
36 hours, RR falls to 4bpm, given naloxone, stabilizes
42 hours, ast269/alt290
44 hours APAP back up to 103
NAC initiated
any thoughts on MOA of delayed absorption? 36 hours from ingestion until resp depression. and apap began elevated, fell, then increased again ...... thoughts?
4 hours post ingestion, serum apap = 105ug/ml, resp rate 20, A/O x 3, ast24/alt18.
8 hours, APAP decreased to 63, pt still stable.
24 hours, pt still stable, ast36/alt36, APAP levels not obtained
36 hours, RR falls to 4bpm, given naloxone, stabilizes
42 hours, ast269/alt290
44 hours APAP back up to 103
NAC initiated
any thoughts on MOA of delayed absorption? 36 hours from ingestion until resp depression. and apap began elevated, fell, then increased again ...... thoughts?