Exogenous Pyrogens

[chromuffin]

Random thought..
Do exogenous pyrogens like LPS act through some other pathway besides via IL-1 secretion from macrophages? Do they act directly on the hypothalamus??

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[KVBane]

Well LPS is released from gram negative bacteria, and was never designed to be a toxin, it just triggers an immune response in T cells, which then activate a systemic immune response, including fever via IL-1. So most likely no, they do not act directly on the hypothalamus.

Don't think of everything that causes a fever as a pyrogen, IL-1 is a pyrogen, LPS is a endotoxin that can result in fevers due to activation of IL-1