Compilation of irreversible competitive inhibitors?

[picmonic freak]

The only irreversible competitive chemicals/drugs that comes to my mind are Aspirin, phenoxybenzamine, and (maybe CO toxin? or that one maybe just has a REALLY high affinity and may be CONSIDERED irreversible). Does anyone have a compilation of these irreversible competitive inhibitors? feel free to correct anything i stated. On line weaver burk plot qs, I'm not confident when it asks about competitive inhibitors because I always wonder: "Is THAT one irreversible?". I currently have the understanding that any chemical that competes for the active site and forms a covalent bond is irreversible competitive inhibitor- (and perhaps chemical whose affinity is so high that they are considered PRACTICALLY irreversible.... but not sure about this one) Thanks a lot!

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[blueforest]

Proton pump inhibitors are irreversible as well.

 

[picmonic freak]

Proton pump inhibitors are irreversible as well.

Oh yea! forgot about that one. Keep them coming!

 

[picmonic freak]

Proton pump inhibitors are irreversible as well.

Just found that Vigabatrin is as well

 

[picmonic freak]

MAOI- irreversibly inhibit MAO.... which is why there needs to be a couple week "washout period" before starting something like an SSRI→ to avoid SS.